The RESPOND Toolkit has been designed to enhance opioid safety screening and communication practices in community pharmacy settings. The toolkit is comprised of a three-module online training course and printable materials, which include an algorithm and checklist for on-site use. These resources have been designed to raise awareness of the opioid epidemic and define community pharmacists’ role in addressing it; improve use of Prescription Drug Monitoring Programs in daily workflow; and facilitate effective and integrated communication between the pharmacists, patients, and prescribers. Funding provided by the Agency for Healthcare Research & Quality (AHRQ 5R18HS024227-02).